Journal
JOURNAL OF NEUROINFLAMMATION
Volume 9, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1742-2094-9-94
Keywords
Parkinson's disease; Leucine-rich repeat kinase 2 (LRRK2); Neuroinflammation; Cytokines
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Funding
- Ministero dell' Istruzione, Universita e Ricerca (Incentivazione alla mobilita di studiosi stranieri e italiani residenti all'estero - Rientro dei Cervelli Program)
- Michael J. Fox Foundation
- CARIPLO Foundation
- University of Padova
- [55YP79]
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Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson's disease; Crohn's disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon., and its function as negative regulator of the immune response transcription factor NFAT1. In this review we discuss the most recent findings regarding how LRRK2 could be a player in the inflammatory response and we propose a scenario where the detrimental effects mediated by Parkinson's disease LRRK2 mutations may initiate in the periphery and extend to the central nervous system as a consequence of increased levels of pro-inflammatory factors permeable to the blood brain barrier.
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