Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 324, Issue -, Pages 129-135Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.08.008
Keywords
Multiple Sclerosis; Non coding RNA; Gene expression; Biomarker
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Funding
- Italian Ministry of Health
- Research Council KU Leuven [C24/16/045]
- Research Foundation Flanders [G.0734.15]
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LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p <= .05 and p <= .0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.
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