Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 269, Issue 1-2, Pages 38-43Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.02.001
Keywords
sirtuin 1; Astrocyte; Superoxide dismutase 2; Catalase; Forkhead box protein 04; Reactive oxygen species
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Advanced Research for Medical Products Mining Program of the National Institute of Biomedical Innovation (NIBIO) of Japan
- Ministry of Health, Labour and Welfare of Japan.
- Grants-in-Aid for Scientific Research [24591258, 24111520] Funding Source: KAKEN
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Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases. Here we investigated the protective functions of SIRT1 in astrocytes, which are the most abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the expression levels of pro-inflammatory cytolcines and increased the expression levels of superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased the acetylation of forkhead box protein 04, decreased the expression levels of superoxide dismutase 2 and catalase, and increased. the production of reactive oxygen species. Our data suggest that astrocytic SIRT1 may elicit neuroprotective effects through its anti-oxidative and anti-inflammatory functions. (C) 2014 Elsevier B.V. All rights reserved.
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