Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 270, Issue 1-2, Pages 56-60Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.02.014
Keywords
Multiple sclerosis; Interleukin-1 beta; Cortical pathology
Categories
Funding
- Istituto Superiore di Sanita
- University of Padova (Progettolnterarea di Ateneo, Prot) [CPDA099394]
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The cerebrospinal fluid levels of interleukin-1 beta and structural magnetic resonance parameters of cortical damage, i.e., cortical lesion number and volume, and global cortical thickness, were analysed in multiple sclerosis patients at clinical onset. Cerebrospinal fluid interleukin-1 beta levels strongly correlated with cortical lesion load and cortical thickness, while correlation with white matter lesion load was modest. Interleukin-1 beta, intrathecally produced by infiltrating lymphocytes and activated microglia, may constitute a possible link between inflammation and neurodegeneration in multiple sclerosis.(c) 2014 Elsevier B.V. All rights reserved.
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