Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 266, Issue 1-2, Pages 33-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.10.012
Keywords
Glioma; Regulatory T cells; Heme oxygenase 1; Tin protoporphyrin; Immunization; Hypoxia
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Funding
- NIH [R01CA138587]
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Two characteristic features of malignant gliomas (MG) are the presence of hypoxia and accumulation of regulatory T cells (Tregs). Heme-oxygenase-1 (HO1) is a cytoprotective enzyme expressed in high level by Tregs in glioma. In this study, we show that higher HO1 expression in Tregs is associated with increased survival under hypoxic conditions and that HO1 inhibitor, tin protoporphyrin (SnPP), abrogates the survival benefits. Moreover, SnPP preferentially eliminates Tregs and treatment with SnPP of tumor bearing mice significantly increases survival (23 to 31 days (p < 0.05)). Thus HO1 inhibition provides another alternative way of therapeutically targeting Tregs in MG. (c) 2013 Elsevier B.V. All rights reserved.
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