Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 276, Issue 1-2, Pages 37-46Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.08.001
Keywords
Prenatal stress; Depression; Pro-inflammatory cytokines; Insulin-like growth factor-1; Suppressor of cytokine signaling
Categories
Ask authors/readers for more resources
Stress, inflammation and the reduced expression of neurotrophic factors are risk factors for depression. The objective of this study was to determine if prenatal stress affects IGF-1 - cytokine interactions by influencing suppressors of cytokine signaling (SOCS) in the brains of adult rats, in basal conditions and after acute lipopolysaccharide (LPS) treatment. We demonstrated that prenatal stress leads to depression-like behavior, decreased IGF-1, increased IL-1 beta, TNF-alpha and IFN-gamma release and disturbed SOCS-1, SOCS-2 and SOCS-3 expression in the hippocampus and frontal cortex of adult offspring. Furthermore, prenatal stress enhances the brain response to LPS-evoked inflammatory challenges. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available