Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 256, Issue 1-2, Pages 55-61Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.12.001
Keywords
Myasthenia gravis; Follicular helper T cells; Inducible costimulator; CXC-chemokine ligand 13; Anti-acetylcholine receptor antibody
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Funding
- National Natural Science Foundation of China [30870850, 81071002]
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Growing evidence has demonstrated that dysfunction of follicular helper T (TFH) cells results in an abnormal positive selection of autoreactive B cells, which contributes to the development of autoimmune diseases. This study reveals that the frequency of circulating counterparts of TFH cells in myasthenia gravis (MG) patients is significantly higher compared to healthy controls. Interestingly, the frequencies of circulating TFH cells were positively correlated with the levels of serum anti-AChR Ab in MG patients. Our data suggest the presence of overactivation and expansion of circulating counterparts of TFH cells in MG patients, which may contribute to the immunopathogenesis of MG. (C) 2012 Elsevier B.V. All rights reserved.
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