Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 262, Issue 1-2, Pages 106-112Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.06.007
Keywords
Th17; Treg; Multiple sclerosis
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The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
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