Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 261, Issue 1-2, Pages 134-140Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2013.05.014
Keywords
Multiple sclerosis; Urocanic acid; Environmental factors; Ultraviolet radiation; Cytokines
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Funding
- Institute for Neurological Research Dr. Raul Carrea, FLENI
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The role of cis-urocanic acid (UCA) as a UV-mediated immunomodulator in MS patients was investigated. Plasma levels of cis-UCA were significantly lower in MS patients compared to controls. Stimulation of MBP- and MUG-specific T cells in the presence of cis-UCA, significantly increased IL-10, and inhibited IFN-gamma production. PBMCs cultured in the presence of cis-UCA increased CD4(+)CD25(+)FoxP3(+) regulatory T cell percentages. Dendritic cells cultured in the presence of cis-UCA significantly reduced Ag presentation capacity. Finally, cis-UCA activated the 5-HT2A receptor, inducing the increase in phosphorylated forms of ERK 1/2 and JNK2. Thus, in addition to vitamin D, cis-UCA also appears to be an additional UV-mediated immunomodulator. (C) 2013 Elsevier B.V. All rights reserved.
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