Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 261, Issue 1-2, Pages 53-59Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.05.003
Keywords
Paraneoplastic cerebellar degeneration; Lambert-Eaton Myasthenic syndrome; Small-cell lung cancer; P/Q-type voltage-gated calcium channel antibodies; Intrathecal injection; Mouse model
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Funding
- Fondo de Investigaciones Sanitarias, Madrid [PS09/0193, PS11/01780]
- Fundacio la Marato de TV3, Barcelona
- Ministerio de Ciencia e Innovacion [SAF2007-64062]
- Instituto de Salud Carlos III (RETICS-Red de Trastornos Adictivos-Redes Tematicas de Investigacion Cooperativa en Salud), Spain [RD06/0001/0001, RD06/0001/1004]
- FEDER funds (EU)
- ICREA Funding Source: Custom
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The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. (C) 2013 Elsevier B.V. All rights reserved.
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