Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 256, Issue 1-2, Pages 77-83Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.12.011
Keywords
Multiple sclerosis; Intrathecal synthesis; IgM; S-nitrosocysteine; S-nitrosylation; Biomarker
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Funding
- National Multiple Sclerosis Society, USA [PP1366]
- Norwegian University of Science and Technology
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This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker. (C) 2013 Elsevier B.V. All rights reserved.
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