Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 254, Issue 1-2, Pages 110-116Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2012.10.005
Keywords
Virus; Cytokines; Neuroinflammation; Demyelination
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Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 and p35 to form the immunomodulatory cytokines IL-27 and IL-35, respectively. Infection of EBI3 -/- mice with the neuroadapted JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality that was not associated with impaired ability to control viral replication but enhanced T cell and macrophage infiltration into the CNS. IFN-gamma secretion from virus-specific CD4+ and CD8+ T cells isolated from infected EBI3 -/- mice was augmented while IL-10 expression muted in comparison to infected WT mice. These data demonstrate a regulatory role for EBI3-associated cytokines in controlling host responses following CNS viral infection. (C) 2012 Elsevier B.V. All rights reserved.
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