Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 249, Issue 1-2, Pages 27-39Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2012.04.010
Keywords
Theiler's murine encephalomyeltis virus; Cerebrum; Phenotyping; Regulatory T cells; Cytokine expression
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [BE 4200/1-1, HU 1300/3-1]
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Reduced protective immunity leads to viral persistence and demyelination in Theiler's murine encephalomyelitis. The aim of the present study was to compare the phenotype of brain-infiltrating leukocytes and cytokine expression in susceptible SJL and resistant C57BL/6 mice during Theilervirus-induced acute polioencephalitis. In contrast to C57/BL6 mice, SJL mice show an increased number of Foxp3(+) regulatory T cells and CD45R(+) B cells associated with delayed viral elimination and elevated IL-10 mRNA transcripts in the brain. Results substantiate the hypothesis that an imbalanced cytokine milieu during the early infection phase contributes to ineffective antiviral immunity in animals with a susceptible genetic background. (C) 2012 Elsevier B.V. All rights reserved.
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