4.3 Article

Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels

Journal

JOURNAL OF NEUROIMMUNOLOGY
Volume 242, Issue 1-2, Pages 33-38

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.10.013

Keywords

Fibromyalgia; Central inflammation; Glia cells; Interleukins; Chemokines; Lumbar puncture

Funding

  1. Swedish Research Council [K2009-53X-21070-01-3]
  2. Swedish Rheumatism Association
  3. Karolinska Institute Foundations
  4. Stockholm County Council

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Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the first study assessing intrathecal concentrations of pro-inflammatory substances in fibromyalgia. We report elevated cerebrospinal fluid and serum concentrations of interleukin-8, but not interleukin-1beta, in FM patients. This profile is in accordance with FM symptoms being mediated by sympathetic activity rather than dependent on prostaglandin associated mechanisms and supports the hypothesis of glia cell activation in response to pain mechanisms. (C) 2011 Elsevier B.V. All rights reserved.

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