Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 242, Issue 1-2, Pages 33-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.10.013
Keywords
Fibromyalgia; Central inflammation; Glia cells; Interleukins; Chemokines; Lumbar puncture
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Funding
- Swedish Research Council [K2009-53X-21070-01-3]
- Swedish Rheumatism Association
- Karolinska Institute Foundations
- Stockholm County Council
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Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the first study assessing intrathecal concentrations of pro-inflammatory substances in fibromyalgia. We report elevated cerebrospinal fluid and serum concentrations of interleukin-8, but not interleukin-1beta, in FM patients. This profile is in accordance with FM symptoms being mediated by sympathetic activity rather than dependent on prostaglandin associated mechanisms and supports the hypothesis of glia cell activation in response to pain mechanisms. (C) 2011 Elsevier B.V. All rights reserved.
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