Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 252, Issue 1-2, Pages 33-39Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2012.07.010
Keywords
Pro-inflammatory; Microglia; Macrophage; Hippocampus
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Funding
- NIDCR NIH HHS [R01 DE021966] Funding Source: Medline
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IL-1RA has been used intra-cerebrally to ameliorate neuroinflammatory responses. The present study explored the possibility that the bioactivity of IL-1RA administered intra-cerebrally may be prolonged in the CNS. hIL-1RA was detected in hippocampus from 2 h to 14 d post-ICM treatment. hIL-1RA ameliorated both the hippocampal cytokine (TNF alpha and NF kappa BI alpha) and sickness response to peripheral LPS administered 4 d after hIL-1RA. Four days post treatment, hIL-1RA reduced the basal expression of IL-1R1, Iba-1, MHCII, and TLR4 and blunted the microglial IL-1 beta and IL-6 response to LPS ex vivo. IL-1RA might be administered prophylactically to prevent the neuroinflammatory effects of trauma. (c) 2012 Elsevier B.V. All rights reserved.
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