Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 244, Issue 1-2, Pages 94-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.12.004
Keywords
Osteopontin; IL-23; Multiple sclerosis
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Funding
- Harbin Special Funds for Research of Scientific and Technological Innovative Talents [2011RFQYS092]
- Innovative Foundation of the Harbin Medical University [HCXS2010014]
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Osteopontin (OPN) and interleukin-23 (IL-23) are pro-inflammatory cytokines proposed to play central roles to the development of multiple sclerosis (MS). The aim of this study was to evaluate levels of OPN, IL-23 and other inflammatory cytokines and investigate their relationships in serum and cerebrospinal fluid (CSF) in patients with MS. Fifty one MS patients and 48 patients with non-inflammatory neurological diseases (NIND) were recruited from clinic. The levels of OPN, IL-23, IL-17, IL-6, and tumor necrosis factor-alpha (TNF-alpha) in serum and CSF were determined in each participant. Compared with NIND group, MS patients had significantly elevated levels of OPN, IL-23, IL-17 and TNF-alpha in CSF, and elevated levels of IL-23, IL-17 and TNF-alpha in serum (All P<0.001). In MS patients, OPN and IL-23 were positively correlated with IL-17 (r = 0.302, P=0.019; r = 0.417, P=0.001, respectively); and IL-23 was positively correlated with EDSS (r = 0.329, P=0.019). Both OPN and IL-23 may play pivotal role in development of MS and might be specific markers and therapeutic targets for MS. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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