Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 243, Issue 1-2, Pages 1-11Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.11.008
Keywords
Multiple sclerosis; CD4(+)CD28(-) T-cells; Activation; NK cells markers; Adhesion molecules; Cytotoxic markers
Categories
Funding
- Fondo de Investigacion Sanitaria (FIS)
- Ministerio de Ciencia e Innovacion [02/0671, 05/1592, CP 03/00042]
- Consejeria de Salud de la Junta de Andalucia [PI 03/0010]
Ask authors/readers for more resources
Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28(-) T-cells. Our aim was to examine whether CD4(+)CD28(-) T-cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC). All these changes could provide these CD4(+)CD28(-) T-cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available