Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 251, Issue 1-2, Pages 90-93Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.06.010
Keywords
Creutzfeldt-Jakob disease; N-methyl-D-aspartate glutamate receptors; Autoantibodies
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Funding
- Research Committee of Prion Disease and Slow Virus Infection
- Ministry of Health, Labour and Welfare of Japan
- Health and Labour Sciences Research Grants for Research on Psychiatry and Neurological Diseases and Mental Health [H20-021]
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Psychiatric symptom can be a prominent feature early in Creutzfeldt-Jakob disease (CJD), which is also common in autoantibody-mediated limbic encephalitis. We hypothesized that anti-neuronal autoantibodies, especially those against N-methyl-D-aspartate glutamate receptors (NMDAR), can also be associated with CJD. Thirteen patients with CJD and 13 patients with limbic encephalitis were enrolled. Immunohistochemistry demonstrated that serum of CJD patients reacted with neuronal components of the rat hippocampus, indicating that those samples contained anti-neuronal antibodies. Enzyme-linked immunosorbent assay revealed that titers of antibodies against peptides of GluN2B subunit of NMDAR were significantly elevated in the serum and cerebrospinal fluid of CJD patients. (C) 2012 Elsevier B.V. All rights reserved.
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