Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 251, Issue 1-2, Pages 6-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.06.004
Keywords
Glia; IL1 beta; MAPK; Neuroinflammation; NF kappa B; SR-A
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Funding
- grant Fondecyt [1090353]
- grant NIH [R03 TW008019]
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Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-kappa B signaling and increased production of IL1 beta and nitric oxide (NO). IL1 beta classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFN gamma-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation. (C) 2012 Elsevier B.V. All rights reserved.
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