Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 230, Issue 1-2, Pages 183-187Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.07.022
Keywords
TLR4; Photoreceptor; IL-6; CXCL1; Inflammation; Apoptosis
Categories
Funding
- National Institute of Health [NS052471, EY018341, EY019250, EY14362, EY018137, EY11373]
- NATIONAL EYE INSTITUTE [R01EY018137, P30EY011373, R01EY014362, R01EY018341, R01EY019250] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS052471] Funding Source: NIH RePORTER
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Toll-like receptor 4 (TLR4) is expressed on a number of cells including neurons in the brain. However, it has yet to be determined if TLR4 is expressed on photoreceptor cells in the retina. In this report, we examined primary photoreceptor cells and an established photoreceptor cell line (661W). We found that functional TLR4 is constitutively expressed on photoreceptor cells, and can be activated by LPS. We conclude that TLR4 on photoreceptor cells could directly contribute to retinal inflammatory diseases and photoreceptor cell survival. (C) 2010 Elsevier B.V. All rights reserved.
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