Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 237, Issue 1-2, Pages 39-46Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.05.013
Keywords
Trigeminal satellite cells; Cortical astrocytes; CGRP; Proinflammatory genes; IL1 beta; Migraine
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Funding
- Merck
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Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1 beta actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1 beta. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes. (C) 2011 Elsevier B.V. All rights reserved.
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