Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 233, Issue 1-2, Pages 245-248Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.01.010
Keywords
Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands
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Funding
- Deutsche Forschungsgemeinschaft [SFB 571-Al]
- German Ministry for Education and Research (BMBF)
- NeuroproMiSe [LSHMCT-2005-018637-WPM5]
- F1SM - Fondazione Italiana Sclerosi Multipla [Cod. 2008/B/3]
- National Health and Medical Research Council of Australia
- National Multiple Sclerosis Society
- Jacob Javits Neuroscience Investigator Merit Award [R37 NS024247]
- US National Institutes of Health [P01A139671]
- National Multiple Sclerosis Society [RG2172C9, RG3308A10]
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We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.
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