Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 238, Issue 1-2, Pages 73-80Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2011.07.001
Keywords
Autism spectrum disorders (ASD); Transcript profiling; Cytokines; CCL2; Peripheral blood (PB) monocytes; TLRs
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Funding
- Jonty Foundation, St. Paul, MN
- Autism Research Institute, San Diego, CA
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Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N = 30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf + GI, N = 19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N = 28) and normal (N = 26) controls. This included a 4-5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf + GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf + GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes. (C) 2011 Elsevier B.V. All rights reserved.
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