Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 237, Issue 1-2, Pages 87-92Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.06.011
Keywords
Autoantibody; Autoimmune diseases; ER stress; GRP94; Immunoprecipitation; Myasthenia gravis
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Funding
- Japanese Ministry of Education, Science, Sports and Culture [23591255]
- Neuroimmunological Disease Research Committee, Japanese Ministry of Health, Labour, and Welfare
- Grants-in-Aid for Scientific Research [23591255] Funding Source: KAKEN
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Immune responses to ER stress have been closely related to the pathogenesis of autoimmune diseases. Using an immunoprecipitation assay, 24 (7.1%) of 336 MG serum samples immunoprecipitated a 90-kDa protein from the muscle cellular extracts, but none of the disease or healthy control sera. The 90-kDa protein was affinity-purified and found to match to ER chaperon GRP94 by matrix-assisted laser desorption/ionization-time of flight mass spectroscopy analysis. The frequency of associated autoimmune diseases was much higher in the anti-GRP94-positive than the -negative patients (71% versus 11%, p<0.001). Autoimmunity to ER chaperone GRP94 is associated with a subset of MG patients who have additional autoimmune diseases. (C) 2011 Elsevier B.V. All rights reserved.
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