Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 233, Issue 1-2, Pages 106-111Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.12.004
Keywords
Adult bone marrow stem cells; Neural differentiation; Immunosuppression; Prostaglandin E2; Experimental autoimmune encephalomyelitis
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Funding
- Medical University of Lodz [502-11-741]
- Polish Ministry of Science and Higher Education [N401 031637]
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Bone marrow mesenchymal stem cells (BMSC)-induced amelioration of experimental autoimmune encephalomyelitis (EAE) was diminished with neuronal differentiantion of BMSC (nBMSC). BMSC secreted large amounts of PGE2, compared to nBMSC, which correlated with higher efficacy to EAE inhibition. EAE mice treated with PGE2 inhibitor, meloxicam showed decreased serum levels of PGE2 and in parallel decreased inhibitory effect on EAE course. In addition, high levels of PGE2 secretion correlated with high expression of indoleamine-2,3-dioxygenase (IDO). Meloxicam blocked IDO expression in BMSC transferred mice indicating functional relation between PGE2 and IDO induction. The current findings demonstrates PGE2 involvement in BMSC-induced inhibition of EAE and provides a mechanistic link between BMSC-derived PGE2 and IDO-dependent immunoregulation of this autoimmune condition. (C) 2010 Elsevier B.V. All rights reserved.
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