Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 232, Issue 1-2, Pages 51-62Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.10.006
Keywords
Astrocytes; Glial fibrillary acidic protein; Aquaporin-4; Gliosis; Neuroinflammation
Categories
Funding
- Trish MS Research Foundation
- NHMRC
Ask authors/readers for more resources
The C57Bl/6 mouse is the preferred host for the maintenance of gene deletion mutants and holds a unique place in investigations of cytokine/chemokine networks in neuroinflammation. It is also susceptible to experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS)-like disease commonly used to assess potential MS therapies. Investigations of glial reactivity in EAE have revealed hitherto undescribed astroglial responses in this model, characterized by progressively diminishing glial fibrillary acidic protein and aquaporin-4 immunostaining, from early disease. These observations show that astrocyte responses vary with the EAE paradigm and are an important pathological criterion for disease mapping and therapy evaluation. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available