Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 239, Issue 1-2, Pages 101-104Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.08.004
Keywords
Multiple sclerosis; Polymorphisms; Interferon-beta; Response
Categories
Funding
- DANA Foundation
- European Community [212877]
- Fondo de Investigacion Sanitaria (FIS)
- Ministry of Science and Innovation, Spain
- Ajuts per donar Suport als Grups de Recerca de Catalunya [SGR 2005-1081]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)
- Generalitat de Catalunya, Spain
- Ministry of Education and Science, Republic of Serbia [175031]
- ICREA Funding Source: Custom
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Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFN beta) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFN beta. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFN beta in MS patients. (C) 2011 Elsevier B.V. All rights reserved.
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