Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 230, Issue 1-2, Pages 10-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.08.006
Keywords
Human; Myeloid cells; Adult microglia; Multiple sclerosis; Fingolimod/FTY720
Categories
Funding
- Multiple Sclerosis Society of Canada
- Canadian Institute for Health Research (CIHR)
Ask authors/readers for more resources
Human microglia, monocyte-derived dendritic cells (DCs) and macrophages ex vivo express relatively higher levels of sphingosine-l-phosphate (SIP) receptor 1 (S1P1) mRNA as compared to other receptor subtypes. The S1P agonist FTY720 decreased ERK phosphorylation and induced myosin light chain (MLC) II phosphorylation only in macrophages and DCs. FTY720 inhibited IL-12p70 production (CD40L induced) by DCs and macrophages but not microglia (poly I:C induced). IL-10 production was increased in DCs and unaffected in other myeloid cells. Despite similar receptor expression patterns, the distinct myeloid cell populations present in the human CNS, under steady-state or inflammatory conditions, exhibit differential responses to FTY720. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available