Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 232, Issue 1-2, Pages 200-206Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.10.015
Keywords
Autoimmunity; Biomarkers; Cathepsins; Immunomodulation; Interferon; Multiple sclerosis
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We investigated the modulation of Cathepsin S, Cathepsin B and Cystatin C expression in immune cells by interferon (IFN)-beta, and their role in cell migration. Cathepsin levels were increased in monocytic and T line cells upon activation. IFN-beta abolished this increase of Cathepsin B in monocytes and of Cathepsin Sin T cells, while increased Cystatin C. Neutralizing Cystatin C increased cell migration, while migration of monocytes and T cells was inhibited by IFN-beta, by Cystatin C, and T cell migration was suppressed by Cathepsin S and B inhibitors. These findings support further studies in the importance of Cathepsins and Cystatins in immunomodulation. (C) 2010 Elsevier B.V. All rights reserved.
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