Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 240, Issue -, Pages 87-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.09.011
Keywords
Multiple sclerosis; Epstein-Barr virus; Vitamin D; Cerebrospinal fluid; EBNA-1; IL-17
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The pathogenesis of multiple sclerosis (MS) may involve intrathecal Epstein-Barr virus nuclear antigen-1 (EBNA-1) specific T cells susceptible to modulation by vitamin D. We established EBNA-1 reactive T cell lines from the cerebrospinal fluid (CSF) and blood of three MS patients and cloned EBNA-1 specific CD4+ T cells from two of these. T cell clones from CSF and blood displayed Th1 or Th17 phenotypes and were restricted by HLA-DR molecules, in one patient encoded by the DRB1*0403 or DRB1*1501 haplotypes. 1,25-dihydroxyvitamin D inhibited proliferation and suppressed secretion of IFN-gamma and IL-17, irrespective of T cell origin and HLA restriction. (C) 2011 Elsevier B.V. All rights reserved.
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