Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 239, Issue 1-2, Pages 44-52Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.08.006
Keywords
Multiple sclerosis; TMEV; SDR; Stress; IL-6; Neuroinflammation
Categories
Funding
- NIH/NINDS [R01-NS060822]
- Research Office at TAMU
Ask authors/readers for more resources
Chronic social disruption stress (SDR) exacerbates acute and chronic phase Theiler's murine encephalomyelitis virus (TMEV) infection, a mouse model of multiple sclerosis. However, the precise mechanism by which this occurs remains unknown. The present study suggests that SDR exacerbates TMEV disease course by priming virus-induced neuroinflammation. It was demonstrated that IL-1 beta mRNA expression increases following acute SDR; however, IL-6 mRNA expression, but not IL-1 beta, is upregulated in response to chronic SDR. Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1 beta mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation. (C) 2011 Elsevier BM. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available