Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 222, Issue 1-2, Pages 76-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.03.004
Keywords
Amyotrophic lateral sclerosis (ALS); Cytokines; Chemokines; Cerebrospinal fluid (CSF)
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
Ask authors/readers for more resources
We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS. CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available