Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 222, Issue 1-2, Pages 29-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.02.018
Keywords
Cytokine; Dexamethasone; Systemic inflammation; Motor behaviour
Categories
Funding
- Pfizer Inc.
- Rene Baron Foundation
- Agencia Nacional de Promocion Cientifica y Tecnologica
- PIP-CONICET
- YPF foundation
Ask authors/readers for more resources
Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1 beta induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1 beta expression can trigger and systemic IL-1 beta exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available