Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 224, Issue 1-2, Pages 56-61Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.05.017
Keywords
Chemokines; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Primary CNS lymphoma; Lymphoid neogenesis; Neuroborreliosis
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Funding
- NINDS NIH HHS [R01 NS047687-03, R01 NS047687-01A1, R01 NS047687-02, R01 NS047687-05, R01 NS047687, R01 NS047687-04] Funding Source: Medline
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Lymphoid chemokines, including CCL19, CCL21 and CXCL13, are critical in the development and organization of secondary lymphoid tissues and in the generation of adaptive immune responses. These molecules have also been implicated in the development of ectopic lymphoid structures in the setting of chronic inflammation. Here we review current knowledge on the production of lymphoid chemokines in the central nervous system during both homeostatic conditions and in disease states. Accumulating evidence suggests that constitutive expression of CCL19 plays a critical immunosurveillance role in healthy individuals. In contrast, aberrant induction of CCL19, CCL21 and CXCL13 may support the establishment of chronic autoimmunity and hematopoetic tumors within the CNS. (C) 2010 Elsevier B.V. All rights reserved.
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