Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 226, Issue 1-2, Pages 8-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.05.026
Keywords
Viral infection; Neuroimmunology; Cytokines; T cells; MHC II; Androgens
Categories
Funding
- Division of Immunobiology
- Cincinnati Children's Hospital Research Foundation
- Public Health Service [NS051798]
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Intracranial (i.c.) lymphocytic choriomeningitis virus (LCMV) infection of mice results in T cell-driven anorexia and weight loss, which is diminished in males compared to females. We investigated sex-specific effects on antigen-presenting cells (APCs) and T cells after i.c. LCMV infection. Numbers of LCMV-specific T cells, APC activation, and levels of inflammatory cytokines and chemokines in CSF were decreased in males compared to females. Orchidectomy enhanced these immune parameters in males, while dihydrotestosterone treatment of orchidectomized males and intact females decreased some of these parameters. These data suggest that qualitative and quantitative effects of androgens on APCs and T cells may contribute to the well-known, but poorly understood sex differences in immunity and autoimmunity. (C) 2010 Elsevier By. All rights reserved.
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