Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 223, Issue 1-2, Pages 131-134Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.03.009
Keywords
Neural precursor cells; Migration; Blood-brain barrier; IL8; CXCL13; Multiple sclerosis
Categories
Funding
- Association pour la Recherche sur la Sclerose en Plaques (ARSEP)
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Departement de la Recherche Clinique et du developpement, Assistance Publique-Hopitaux de Paris
Ask authors/readers for more resources
It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines 18 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro, in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available