Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 226, Issue 1-2, Pages 143-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.05.032
Keywords
Multiple sclerosis; MRI; IgG oligoclonal bands; IgM oligoclonal bands; Clinically isolated syndrome
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Funding
- Carlos III Institute from Spain [FIS PI060822, PS09/01652, PS09/01338]
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We prospectively assessed the risk of second relapse in 192 patients with clinically isolated syndromes (CIS) divided into three groups: patients lacking oligoclonal IgG bands (OC-IgG, 25.7%), those showing OC-IgG (52.4%), and those with both OC-IgG and lipid-specific IgM bands (LS-OC-IgM, 22%). OC-IgG increased 9.3-fold the risk compared to lacking OC-IgG; OC-IgG+LS-OC-IgM increased the risk 39.6-fold compared to not having OC-IgG and 4.4-fold compared to having only OC-IgG. Median time to second relapse was 0.7 years for patients with OC-IgG+LS-OC-IgM and 3.3 years for those with only OC-IgG. Therefore, CSF analysis identifies CIS patients at risk of second relapse. (C) 2010 Elsevier B.V. All rights reserved.
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