Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 220, Issue 1-2, Pages 108-113Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.01.007
Keywords
Pain; Osteoarthritis; Inflammation; Glial cell line-derived neurotrophic factor; Cerebrospinal fluid; Cytokines
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Funding
- Sahlgrenska University Hospital, Gothenburg, Sweden [ALF-LUA 76370]
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Glial cell line-derived neurotrophic factor (GDNF) is involved in inflammation and pain, roles which remain to be delineated clinically. We aimed to evaluate the role of central nervous and peripheral GDNF in long-term pain patients and in controls by analysing intrathecal and blood concentrations of GDNF. Simultaneous measurements of pro-inflammatory cytokines IL-1 beta, TNF-alpha and IL-6, anti-inflammatory cytokine IL-10 and chemokine IL-8 served to define inflammatory responses. Generally, blood levels of GDNF were higher than corresponding intrathecal levels. Pain was associated with levels of GDNF that were increased intrathecally, but decreased in blood. IL-8 was uniformly higher in pain patients. (C) 2010 Published by Elsevier B.V.
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