Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 226, Issue 1-2, Pages 172-176Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.07.006
Keywords
Multiple sclerosis; HLA class I; HLA-C; HLA-A; HLA-DRB1; Genetic association
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Funding
- Bibbi and Nils Jensen Foundation
- Swedish Research Council, Karolinska Institutet
- European Union, NeuroproMiSe [LSHM-CT-2005-018637]
- Research Council of Norway [166005/V50]
- Odd Fellow MS Society
- MS society of Norway
- South and Eastern Norway Regional Health Authority
- Scientific Advisory Council at Oslo University Hospital, Ulleval
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Objective: The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation. Methods: 1529 MS patients and 1814 controls from Sweden and Norway were genotyped for HLA-DRB1, HLA-A, and HLA-C. Simultaneous analysis of all alleles while adjusting for confounding was achieved using logistic regression. Results: We observed independent effects of all three genes. We confirm the HLA-A*02 (OR=0.73, p=9.2x10(-4)) association and report a novel effect of HLA-C*08 (OR= 1.85, p=0.0093). Conclusions: The HLA class I region contains two factors modulating MS risk, characterized by independent associations with HLA-A and HLA-C. (C) 2010 Elsevier B.V. All rights reserved.
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