Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 223, Issue 1-2, Pages 13-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.03.018
Keywords
Systemic lupus erythematosus; Depression; Fatigue; Type-I interferon
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Funding
- NIH [AR40391, M01-RR00082-41, DK07518]
- Lupus Link, Inc. (Daytona Beach, FL)
- Lupus Foundation
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Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.
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