Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 219, Issue 1-2, Pages 105-108Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.11.014
Keywords
Autoantibody; Multiple sclerosis; Neuromyelitis optica; Phosphoglycerate mutase 1; Proteome
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Funding
- Japanese Health and Labor Sciences Research [H18-026]
- Japan Society for the Promotion of Science (JSPS) [1690486]
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We identified the autoantibody against phosphoglycerate 1 (PGAM1). which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis. We further searched this autoantibody in sera from patients with other neurological diseases The prevalence of the anti-PGAM1 antibody is much higher in patients with MS and neuromyelitis optica (NMO) than in those with other neurological diseases and in healthy controls It was reported that the anti-PGAM1 antibody is frequently detected in patients with autoimmune hepatitis (AIH) Results Of Our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases (C) 2009 Elsevier B.V. All rights reserved
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