Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 224, Issue 1-2, Pages 85-92Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.05.012
Keywords
AMPA receptors; Hippocampal neurons; Adenosine; Adenosine receptors; Chemokines; Current modulation; Fractalkine; EPSC
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We characterized the role of adenosine receptor (AR) subtypes in the modulation of glutamatergic neurotransmission by the chemokine fractalkine (CX(3)CL1) in mouse hippocampal CA1 neurons. CX(3)CL1 causes a reversible depression of excitatory postsynaptic current (EPSC), which is abolished by the A(3)R antagonist MRS1523, but not by A(1)R (DPCPX) or A(2A)R (SCH58261) antagonists. Consistently, CX(3)CL1-induced EPSC depression is absent in slices from A(3)R(-/-) but not A(1)R(-/-) or A(2A)R(-/-) mice. Further, A(3)R stimulation causes similar EPSC depression. In cultured neurons. CX3CL1-induced depression of AMPA current shows A(1)R-A(3)R pharmacology. We conclude that glutamatergic depression induced by released adenosine requires the stimulation of different ARs. (C) 2010 Elsevier B.V. All rights reserved.
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