Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 220, Issue 1-2, Pages 131-135Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.01.014
Keywords
HLA-E; HLA-G; Microglia; Glioblastoma
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Funding
- Ministry of Health of the Czech Republic, EU [IGA MZCR 9875-4, IGA MZCR 9871-4]
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The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of FILA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study. (C) 2010 Elsevier B.V. All rights reserved.
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