Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 218, Issue 1-2, Pages 12-20Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.11.005
Keywords
Chronic mild stress; Hippocampus; Learning and memory; Th1/Th2 balance; Reactive oxygen species; BALB/c and C57BL/6 inbred strains of mice
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Funding
- CONICET [PIP 6049, PIP 00281]
- University of Buenos Aires [UBACyT M024]
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This work shows a comparative study on the effects of chronic mild stress upon learning and memory and immunity, in BALB/c and C57BL/6 mice. Stressed BALB/c, but not C57Bl/6 mice, showed a poor learning performance, morphological alterations in the hippocampus with an increase in oxidative stress. A Correlation between poor memory performance and the increase of the Th2/Th1 balance was found. Our results suggest that vulnerability to cognitive deficit associated with stress exposition could be related to a differential regulation of Th1/Th2 cytokine balance, suggesting a better learning performance for individuals that produce Th1 type cytokine after stress exposition. (C) 2009 Elsevier B.V. All rights reserved.
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