Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 229, Issue 1-2, Pages 112-122Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.07.020
Keywords
Neuropsychiatric lupus; Autoantibodies; Depression; Sex difference
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Funding
- NIAMS NIH HHS [R01 AR048692] Funding Source: Medline
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Emotional disturbances are among the most common neuropsychiatric manifestations of SLE, a systemic autoimmune disease with a strong female predominance. In this study, we evaluated young MRL/lpr mice, directly comparing males and females. MRL/lpr females exhibited significant depression as early as 5 weeks (at which time elevated levels of autoantibodies were already present), as compared to MRL/lpr males, where depression was noted only at 18 weeks. Depression was significantly correlated with autoantibodies against nuclear antigens, NMDA receptor, and ribosomal P. Our results are consistent with a primary role of autoantibodies in the pathogenesis of early neuropsychiatric deficits in this lupus model, which translate into gender-based differences in clinical phenotype. (C) 2010 Elsevier B.V. All rights reserved.
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