Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 226, Issue 1-2, Pages 20-26Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.05.030
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Funding
- Irish Research Council for Science, Engineering and Technology
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Inflammation is involved in the pathology of Parkinson's disease, a disorder characterised by degeneration of dopaminergic neurons. This study demonstrates that conditioned medium (CM) from lipopolysaccharide (LPS)-treated rat glial-enriched cortical cultures induced death of embryonic rat dopaminergic neurons in vitro, an effect which was additive to the toxicity of the neurotoxin 6-hydroxydopamine. Interleukin-1 beta (IL-1 beta) in the CM may mediate this neuronal death. IL-1R1 was found to be expressed on dopaminergic neurons. Blockade of IL-1R1 prevented CM-induced dopaminergic neuronal death. This study suggests that IL-1 beta in CM from LPS-stimulated glia contributes to dopaminergic neuronal death induced by glia-conditioned medium. (C) 2010 Elsevier B.V. All rights reserved.
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