Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 206, Issue 1-2, Pages 121-124Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.09.017
Keywords
Amyotrophic lateral sclerosis (ALS); Lipopolysaccharide (LPS); Monocyte/macrophage activation
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Funding
- National Institutes of Health's (NIH) [U01-CA066529]
- National Cancer Institute's West Coast AIDS and Cancer Specimen Resource (ACSR) Consortium
- University of California, San Francisco (UCSF)
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The present study reports elevated levels of endotoxin/lipopolysaccharicle (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS. (C) 2008 Elsevier B.V. All rights reserved.
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