Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 210, Issue 1-2, Pages 73-79Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.02.012
Keywords
Amyotrophic lateral sclerosis (ALS); Motor neuron disease; Immunologic alteration; T lymphocyte; Regulatory T cell
Categories
Funding
- Vialli-Mauro Foundation for research and sport
- Ministero della Salute, Ricerca Finalizzata
Ask authors/readers for more resources
In this work we show that patients with sporadic amyotrophic lateral sclerosis exhibit immunological alterations in their blood, with respect to healthy controls, such as: i) increased levels of CD4+ cells and decreased levels of CD8+ T lymphocytes, the latter due to the reduced expression of the anti-apoptotic molecule Bcl-2; ii) significantly reduced CD4+CD25+ regulatory T (Treg) cells and monocytes (CD14+) levels in patients at a less severe stage of disease, suggesting their early recruitment towards the CNS area of primary neurodegeneration; iii) reduced expression of HLA-DR and CCR2 expression, as markers of activation, in monocytes. Since resident microglia partially derives from circulating activated monocytes and Treg cells are known to interact with the local microglia, this study strengthens the hypothesis of an involvement of the adaptive immune system associated with a neuroinflammatory process in the pathobiology of ALS. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available