Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 207, Issue 1-2, Pages 111-116Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.12.002
Keywords
Autistic spectrum disorders (ASD); Cytokines; Inflammation; Immune response; Flow cytometry method; Multiplexed bead analysis
Categories
Funding
- NYS office of Mental Retardation and Developmental Disabilities
- Autism Speaks
- Autism Research Institute
- Alexander and Bo Maclnnis
Ask authors/readers for more resources
This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available