Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 206, Issue 1-2, Pages 32-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.10.009
Keywords
Neural progenitor cell; beta III-tubulin; Cell cycle; p27; Neurosphere
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Funding
- Bayer Healthcare Pharmaceuticals [NSV-015]
- National Health and Medical Research Council of Australia [454384]
- NHMRC
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Interferons are produced following neural damage as part of the inflammatory response and may thus affect neural stem cell function. We compared the effects of interferon-gamma and interferon-beta on the proliferation and differentiation of adult murine neural progenitors. Both interferons inhibited neurosphere proliferation due to cell cycle arrest in G1 but only interferon-gamma induced neuronal differentiation. Both interferons induced differential phosphorylation of STAT proteins and a modest and late upregulation of the cell cycle regulator p27 but not several other likely cell cycle regulators. Thus in neural progenitor cells, anti-proliferative effects of interferons are not necessarily linked to differentiation. (C) 2008 Elsevier B.V. All rights reserved.
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